Production of cocrystals in an excipient matrix by spray drying
نویسندگان
چکیده
منابع مشابه
The production of Yarrowia lipolytica lipase powder by improved spray-drying method
Lipase is used in the production of foods, flavor enhancers, detergents, cosmetics and pharmaceuticals. A common impediment to the production of commercial enzymes is their low-stability aqueous solutions. In this study, the downstream process was investigated to obtain a stable spray-dried lipase powder of Yarrowia lipolytica. The enzyme solution samples were supplemented with different concen...
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Pharmaceutical cocrystals are used as a strategy to overcome poor physicochemical properties of drugs. The use of cocrystals in the pharmaceutical industry remains to be fully exploited due, in part, to the scarcity of suitable large-scale production methods and lack of robust and cost-effective processes. To overcome these challenges, spray congealing was used for the first time in the prepara...
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Introduction: In the recent years, attention to the use of probiotic drugs and probiotic food products, due to probiotic’s functional and health properties has been increased. The storage and the viability of the probiotics in the products and passing through the gastrointestinal tract was always a big challenge. Drying is one of the functional and important choices that can be used for stabili...
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The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2018
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2017.12.020